Greater, more durable responses vs chemotherapy1
TRODELVY helped patients experience significantly greater overall response rates vs single-agent chemotherapy*†1
*Based on ORR for TRODELVY and single-agent chemotherapy as shown in Table 3 of the Summary of Product Characteristics.1
†Assessed by independent central review in the ITT population. The ORR results in the primary analysis population (ORR: 35% vs 5%; OR: 10.8; 95% CI, 5.6–21.0) were consistent with the ITT population.2 The primary analysis population consisted of patients without present or prior history of brain metastases (n=468). The ITT population consisted of patients with or without brain metastases at baseline (N=529). 1 ‡Assessed by independent central review in the ITT population.2 CR defined as disappearance of all target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 mm.3 §Assessed by independent central review in the ITT population.2 PR defined as at least a 30% decrease in the sum of diameters of target lesions, taking as reference the baseline sum diameters.3 IIAssessed by independent central review in the ITT population. Clinical benefit rate defined as a CR, a PR, or stable disease with a duration of at least 6 months.
ABBREVIATIONS:
CI, confidence interval; CR, complete response; DOR, duration of response; ITT, intent-to-treat; OR, odds ratio; ORR, objective response rate; PR, partial response.
REFERENCES:
- TRODELVY (sacituzumab govitecan) Summary of Product Characteristics. February 2023.
- Bardia A, et al. N Engl J Med. 2021;384(16):1529–1541.
- Eisenhauer EA, et al. Eur J Cancer. 2009;45(2):228–247.